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5 Severe Hormonal Acne Treatments

Severe Hormonal Acne

5 Severe Hormonal Acne Treatments

No one wants to walk around with severe hormonal acne, and if you suffer from this condition, then you probably want to get rid of it as soon as possible. Severe hormonal acne, also known as breakout acne or adult acne, is particularly tough to treat since it tends to be deep within the skin and therefore resistant to topical treatments. But there are still some effective severe hormonal acne treatments that are worth trying even if they aren’t your first choice of treatment. Here are 5 severe hormonal acne treatments that work.

1) Tretinoin Cream

The active ingredient in Tretinoin cream is tretinoin. It is a topical form of vitamin A that promotes cell turnover and accelerates exfoliation. It increases collagen production and speeds up skin renewal, thereby diminishing acne scars and improving texture. To fight acne effectively with Tretinoin cream, you need to start using it on a reguregularly one of your severe hormonal acne treatment plans. The effects are not instantaneous, so don’t expect them to start working overnight but don’t give up if you see no results after a week or two either, the treatment takes time (1-3 months) for you to see full results.

2) Spironolactone

Spironolactone is an effective severe hormonal acne treatment that can be prescribed by your dermatologist or GP. Spironolactone is used for both men and women as a treatment for hormonal acne, as well as other skin conditions such as rosacea. Spironolactone works to reduce sebum production and stabilizes your hormones. If you suffer from severe hormonal acne, ask your doctor about using spironolactone topically in addition to its use orally.

3) Minocycline (Minocin)

Minocycline is an anti-inflammatory antibiotic. It’s typically used to treat acne, rheumatoid arthritis, and gum disease. It is effective in treating severe hormonal acne by decreasing sebum production and slowing follicular hyperkeratinization. Just be sure to use it long-term as it can cause sun sensitivity, and if you're a woman of childbearing age, don't take minocycline because it's classified as a category D drug (meaning there's evidence that taking it during pregnancy can cause birth defects). Even so, it's still one of your best options for clearing up hormonal cystic acne, especially if you combine it with benzoyl peroxide or azelaic acid.

4) Megestrol Acetate (Megace)

Megestrol acetate is one of several forms of estrogen-based treatments for severe hormonal acne. It’s available only with a prescription and works by balancing out your body’s natural levels of estrogen and progesterone. Megestrol can also make your skin more sensitive to light, so be sure to use SPF 30 sunscreen daily.

The most common side effects associated with megestrol are fluid retention, increased appetite, weight gain, swelling in your extremities, and excessive hair growth on your face or arms. If you experience these symptoms while taking megestrol it might be wise to switch medications because they could indicate an adverse reaction that requires immediate medical attention.

5) Antibiotics (Doxycycline, Erythromycin, etc.)

These medications kill bacteria, such as P. acnes, that cause acne by interfering with their ability to create acne-causing toxins. To work well, antibiotics need to be taken for several months at a time; severe hormonal acne might require up to a year of treatment. 

As a general rule, use antibiotics only when prescribed by your doctor, and don't take them if you don't see improvement after two months of use. Talk to your dermatologist about how and when to stop taking these medications to get rid of severe hormonal acne completely. And never share your antibiotics with anyone else, especially if they're not your family members.


If you’re suffering from severe hormonal acne, it’s important to treat it right away. The best way to get rid of your acne is to seek professional advice and treatment, such as over-the-counter medications or a consultation with a dermatologist. Discuss your acne symptoms with your doctor and come up with a plan for how to get rid of severe hormonal acne.

If you try over-the-counter medication alone and don’t see any improvement, consult your doctor about using prescription treatments. Just remember that different treatments work differently for everyone so make sure you discuss them with a professional before you decide which one is right for you.

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